Factual error: Izzie tells her patient, Cheyenne and her mother, Mrs. Ward that they live in the same town she grew up in - Chehalis, Washington, yet mispronounces it. She says CH-halis (like CHurch) when it is SH-halis like Chinook Salmon.
Continuity mistake: When Derek gives Meredith a white bag to hyperventilate into when she is crying in the closet, the large orange sticker on the side of the bag disappears and then reappears again. (00:35:30)