Continuity mistake: When they pick up Warren on the stagecoach, the second shot from inside has the wrong direction of landscape outside, so it seems that Warren changed from the front to the back row.
The Hateful Eight (2015)
Plot summary
Directed by: Quentin Tarantino
Starring: Samuel L. Jackson, Kurt Russell, Tim Roth, Channing Tatum, Jennifer Jason Leigh
Genres: Western
In the dead of a Wyoming winter a few years after the Civil War, a bounty hunter (John Ruth) with his prisoner (Daisy), another bounty hunter (Major Warren) and the newly-elected Sheriff of Red Rock (Mannix) find shelter in a remote country store already inhabited by four strangers - a caretaker and 3 others seeking shelter from an approaching storm. Unbeknownst to the bounty hunters, the four strangers are part of a criminal gang who already killed the store owner and employees. They are there to rescue the prisoner, who is the sister of one of the gang members. As they all hunker down against the storm, John Ruth and the stagecoach driver are poisoned and die. Major Warren, shocked by the poisoning and now suspicious of the motives of the 4 strangers, unleashes a blood bath of violence that kills everyone leaving Mannix and himself mortally wounded, with the prisoner receiving her rightful justice.
Major Marquis Warren: When the handbill says "dead or alive", the rest of us just shoot you in the back from up on top a perch somewhere and bring you in dead over a saddle. When John Ruth the Hangman catches you...you hang.
Trivia: The guitar that Domergue plays and that was subsequently destroyed by Ruth was a priceless antique from the 1870's on loan from the Martin Guitar Museum. Six replicas were made for the film, however Kurt Russell was misinformed and destroyed the original. Due to this the Martin Guitar Museum said they would never lend an instrument to film shoots ever again. (01:38:00 - 01:42:30)
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Answer: It's not PURELY fictional, as plenty of poisons lead to vomiting and bleeding (cyanide, arsenic, etc.), but Tarantino, as is his wont, definitely takes some artistic license and kicks it up several notches for dramatic/gross-out effect.